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What are the mechanisms underlying inflammatory responses and cytokine storm syndromes, including the dysregulation of cytokine signaling pathways such as interleukin-6 (IL-6) and tumor necrosis

What are the mechanisms underlying inflammatory responses and cytokine storm syndromes, including the dysregulation of cytokine signaling pathways such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and the immuno pathogenesis of autoimmune and autoinflammatory diseases?  

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