What is the appropriate "email response?"

I bought my house in 1980 for $75,000.1 talked to a realtor, and the realtor believes that my husband and I can sell the property for at least $300,000. Supposing that this is the case and we sale the property in May of 2023, what will the tax consequences be? We have lived in the house since we bought it and have put in about $35,000 of improvements that we have documentation for. Also, the realtor estimates about $25,000 of closing costs for the sale. If we had been renting the house, would that change how the sale of the property is taxed? Thanks, Client