what is the reserach design for this study, Seventeen studies were prospective, of which 15 included multivariate analysis.9-14,16-24 Methodology was mainly case-control studies,9-14,16-23 accompanied by a case series24 and a 2014 meta-analysis of 4 studies that provided the only level 1 evidence.25 Most evidence was level II. One well-informed expert committee report (level III evidence) was also included