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What is the significance of mitochondrial biogenesis, and how do transcription factors like PGC-1 and NRF1 coordinate the activation of nuclear genes that promote mitochondrial

  1. What is the significance of mitochondrial biogenesis, and how do transcription factors like PGC-1α and NRF1 coordinate the activation of nuclear genes that promote mitochondrial growth and function ?

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Mitochondrial biogenesis is the process by which cells increase the number and size of mitochondria in response to various stimuli such as changes in energy demand environmental stresses or cellular s... blur-text-image

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