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What is the word we use to describe the challenge in statistical measurement that arises when we suspect that the two groups in comparison are

What is the word we use to describe the challenge in statistical measurement that arises when we suspect that the two groups in comparison are fundamentally different? For example, data may show that people who take vitamin c daily are healthier than those who don't but what if those who take vitamin C are also people who lead healthier lifestyles than those who don''t take vitamin C?

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