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What's substrate channeling? What's the biological significance? How is it similar to alpha-ketoglutarate DH? Dehydrogenases: What are common features: chemistry, cofactors, thermodynamics?

What's substrate channeling? What's the biological significance? How is it similar to alpha-ketoglutarate DH? Dehydrogenases: What are common features: chemistry, cofactors, thermodynamics?

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