Whatwhat is one of the biggest differences between supervise and unsupervised learning machine? Supervise learning machine works with massive data sets. Well unsupervised learning does not really use much data. Supervise learning works with machine. Learning algorithms well and supervise learning is always done by artificial Neuro network. Supervise learning classified data into human created categories while unsupervised learning clusters, data into machine created groups.su Supervise machine learning requires a lot of processing power while unsupervised machine. Learning is very lightweight.