Which keyboard shortcut will reload a webpage and clear its cache?

Ctrl and Shift and R $($PC$)$ or Command and Shift and R

$($Mac$)$

Ctrl and D $($PC$)$ or Command and D $($Mac$)$

Ctrl and N $($PC$)$ or Command and N $($Mac$)$

Ctrl and $T(PC)$ or Command and $T($Mac$)$