Which statement about the regulation of carbohydrate metabolism in muscle is true?

A) Epinephrine stimulates biosynthesis of glycogen from glucose-1-phosphate

B) Hormone-stimulated cascades are not necessary, as hormones target only liver metabolism

C) Glucagon stimulates gluconeogenesis, so that the cells will have more glucose for ATP generation

D) Pyruvate kinase is phosphorylated and inactivated in response to epinephrine

E) PP1 deactivates glycogen phosphorylase when the tissue is at rest