Why are changes in nucleosome spacing important in changing geneexpression?

Select the two correct answers.

When DNA is unmethylated and histones are acetylated,nucleosomes are spaced in the open configuration and transcriptioncan occur.

When DNA is methylated and histones are deacetylated,nucleosomes are relatively close together and transcription issuppressed.

Nucleosome spacing depends on maternal and paternal imprintingand influences organismal adaptability to environmentalstress.

When DNA is phosphorylated or methylated and histones areacetylated, transcriptional activity is stimulated at specific DNAregions.