write an introduction: Regression to the Mean refers to the statistical tendency of extreme data points to move towards the average in subsequent measurements (Jhangiani et al., 2019). Spontaneous Remission is the unexplained improvement or cure of a condition without clear treatment (Jhangiani et al., 2019). History, in research design, pertains to events between two measurements in an experiment that can affect the outcome (Jhangiani et al., 2019). Maturation denotes natural changes over time, which can influence behavior changes in research, independent of intervention effects (Jhangiani et al., 2019). These concepts are crucial in interpreting research results, highlighting the need to consider various factors that can influence study outcomes. As indicated several factors may have an impact on the outcomes of a study including obese adolescents taking part in a program to promote increased physical activity and weight assessment both before and after the program. The following are some possible modifications or safety measures to handle each of these concerns and how they might impact the outcome