(p. 77). Recall that two important values computed from the testing phase are the fraction of compound unbound to plasma (fup) and the fraction of compound unbound to microsomes (fumic). A key formula for assessing stability assumes that the fup/fumic ratio is 1:1. Pharmacologists at Pfizer Global Research and Development tested 416 drugs and reported the fup/fumic ratio for each. These data are saved in the FUP file. Suppose the pharmacologists want to determine if the true mean ratio, m, differs from 1. The results of a large-sample test are provided in the accompanying StatCrunch printout. FUP NW

a. Specify the null and alternative hypotheses for this test.

b. Locate the sample mean on the printout and note that it is less than 1. Consequently, a pharmacologist wants to reject the null hypothesis. What are the problems with using such a decision rule?

c. Locate values of the test statistic and corresponding p-value on the printout.

d. Select a value of

a, the probability of a Type I error. Interpret this value in the words of the problem.

e. Give the appropriate conclusion, based on the results of parts c and

d. f. What conditions must be satisfied for the test results to be valid?