(1) H0" population death rate - 0.052. Hi" population death rate

= 0.50. (2) Any difference found will not be used in clinical decisions but will tell the investigator that a different baseline death rate should be calculated for intubated patients. Thus, there is no clinical reason for different c~'s and /3's; they are both chosen as 0.05. From Eq. (25.4), the critical values are 0.05/0.95 - 0.0526 and 0.95/0.05- 19.

(3) The first intubated patient is patient 32, who survived. D1 =

[1 - P(11H1)]/[1 - P(IlH0)] = [1 - 0.50]/[1 - 0.052] = 0.5274. This will also be the multiplying increment in Eq. (25.5) for each surviving patient, and [P(IlH1)]/[P(IlHo)] - [0.50]/[0.052] - 9.6154 will be the multiplying increment for each dying patient. (4) Table 25.8 provides a completed version of Table