Question: Look at Figure 17.8 and predict what would happen if the SRP RNA was unable to stimulate the GTPase activities of the GTPbinding proteins within

Look at Figure 17.8 and predict what would happen if the SRP RNA was unable to stimulate the GTPase activities of the GTPbinding proteins within SRP and the SRP receptor.

Figure 17.8 

5' 5 in in Ribosome Cytosol ER membrane 3 NH3 ER signal

sequence As a polypeptide is being made, SRP binds to an ER

5' 5 in in Ribosome Cytosol ER membrane 3 NH3 ER signal sequence As a polypeptide is being made, SRP binds to an ER signal sequence and causes translation to pause. 3' SRP SRP binds to an SRP receptor in the ER membrane, which is located next to a channel. For this binding to occur. proteins within SRP and the SRP receptor must also be bound by GTP. GTP GTP 3 ER lumen Channel SRP receptor

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