Phenylpropanolamine (PPA) has long been an ingredient in many cold remedies and appetite suppressants. In late 2000,

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Phenylpropanolamine (PPA) has long been an ingredient in many cold remedies and appetite suppressants. In late 2000, the FDA asked manufacturers to remove products containing this compound from the market because of evidence of an increased risk of hemorrhagic stroke. This action has caused a switch to the safer pseudoephedrine as the active component of such medications. 

OH NH2 OH NHCH3 -CH-CH-CH3 CH-CH-CH3 Phenylpropanolamine Pseudoephedrine

Suppose that you are the director of a major pharmaceutical laboratory with a huge stock of phenylpropanolamine on hand and the president of the company issues the order, “Pseudoephedrine from now on!” Analyze all your options, and propose the best solution that you can fi nd for the problem.


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Organic Chemistry structure and function

ISBN: 978-1429204941

6th edition

Authors: K. Peter C. Vollhardt, Neil E. Schore

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