A lipid-soluble hormone, estrogen, is secreted from the ovaries. This molecule travels through the body via the bloodstream. A researcher was interested in reducing estrogen’s effect in order to determine the response of decreased estrogen on the organism. Which of the following is a valid strategy for reducing effects of estrogen on the whole research organism?
(A) Treat with a competitive inhibitor drug that blocks all receptors at the plasma membrane
(B) Treat with lipid-soluble testosterone
(C) Treat with a lipid-soluble noncompetitive inhibitor that specifically reduces estrogen binding to the intracellular receptor
(D) Remove ovaries of the organism