Which of the following statements regarding enzymes is true? 1. Enzymes decrease the free energy change of

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Which of the following statements regarding enzymes is true?

1. Enzymes decrease the free energy change of a reaction.

2. Enzymes increase the rate of a reaction.

3. Enzymes change the direction of chemical reactions

4. Enzymes are permanently altered by the reactions they catalyze.

5. Enzymes prevent changes in substrate concentrations.

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