6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases. (a) Which intermediate or intermediates in purine nucleotide biosynthesis would you

Question:

6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases.

(a) Which intermediate or intermediates in purine nucleotide biosynthesis would you expect to accumulate in DON-treated cells?
(b) Which participants in pyrimidine synthesis?
(c) Speculate on the mechanism by which DON inhibits these enzymes.

Fantastic news! We've Found the answer you've been seeking!

Step by Step Answer:

Related Book For book-img-for-question

Biochemistry Concepts and Connections

ISBN: 978-0321839923

1st edition

Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews

See More Books

Question Posted: Apr 21, 2016 04:22 AM

See More Questions

Sulfonamide drugs like sulfanilamide inhibit tetrahydrofolate biosynthesis. What intermediate or intermediates in purine synthesis would you expect to accumulate in sulfanilamide-treated bacteria?...
Which acid of each pair shown here would you expect to be stronger? (a) (b) (c) (d) (e) HO HO 10 HO HO 3 10 F O or OH OH or MeJN OH OH or CF
Which alkyl halide would you expect to be more reactive in an E2 reaction? a. b. c. d. CH3 CHCHCHCH.CH, or CH.CHCH CHCH. Br Br Br CH3CH2CH CHCH3 or CH3CH2CHCH CH3 CH2CHCH2CH3 or CH2CH CHCH3
In subsurface pipe drainage, describe the different types and materials used for the drainage?
GAAP requires that a company report certain obligations due on demand within one year (or operating cycle, if longer) as current liabilities. Do you agree with this statement? Explain.
Gonzales SA, a financial advising company, has the following transactions during August of the current year, its first month of operations. Indicate (a) the effect on the accounting equation and (b)...
Discuss some of the benefits and problems that informal organizations may bring to both a work group and an employer. lop5
Refer to the Professional Judgment in Context feature "Thor Industries, Inc. and Mark Schwartzhoff: Fraudulent Reductions in Cost of Goods Sold Through Manipulation of Inventory Accounts." Answer the...
On January 1 , 2 0 2 4 , the general ledger of 3 D Family Fireworks includes the following account balances: \ table [ [ % , 3 , January 1 5 , Allowance for uncollectible accounts, 1 , 0 0 0 , ] , [...
Listed below are amounts of arsenic in samples of brown rice from three different states. The amounts are in micrograms of arsenic and all samples have the same serving size. The data are from the...
As stated in the text, bacteriophages have been discovered with the following base substitutions in their DNA: (a) dUMP completely substituting for dTMP (b) 5-hydroxymethyl-dUMP completely...
Consider either the purinosome or a multifunctional protein such as the CAD protein, and propose one or two experiments to determine whether the enzyme "channels" substrates through a multistep...
What is the effect on the current period income statement and the balance sheet when inventories are written down using the lower of cost or market method? What is the effect on future period income...
What is current divider rule?Explain with a suitable example.
How do we design a Successive Approximation Register using PSPICE software?
1.Differentiate between a leader and a manager. 2.Highlight the sources of leadership power. 3.Highlight the styles of leadership and the one which is applicable in a small business. 4.Examine some...
Arrange the following series of compounds in order of increasing lattice energies. (a) NaBr, NaCl, KBr (b) MgO, CaO, CaCl 2 (c) LiF, BeF 2 , BeO
You are a U.S. investor who purchased British securities for 2,000 one year ago when the British pound cost U.S. $1.50. What is your total return (based on U.S. dollars) if the value of the...
What types of homogenization techniques are available for solubilizing a protein?
An isolated strain of sheep was found in New Zealand. Most of these sheep carried the gene for predisposition to scrapie, yet none of them ever came down with the disease. How do these facts relate...
Severe combined immunodeficiency disease (SCID) is characterized by the complete lack of an immune system. Strains of mice have been developed that have SCID. When SCID mice that carry genetic...
The payroll register of Ruggerio Co. indicates $13,800 of social security withheld and $3,450 of Medicare tax withheld on total salaries of $230,000 for the period. Federal withholding for the period...
All of the following are included on Form 1040, page 1, EXCEPT: The determination of filing status. The Presidential Election Campaign check box. The income section. The paid preparer signature line.
Question One: (25 marks) (X) Inc. purchased 80% of the outstanding voting shares of (Y) for $360,000 on July 1, 2017. On that date, (Y) had common shares and retained earnings worth $180,000 and...

6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases. (a) Which intermediate or intermediates in purine nucleotide biosynthesis would you

Question:

CH2 CH2 H-C-NH COO

Step by Step Answer:

a PRPP Formylglycinamide ribonucleotide intermediate 4 in IMP synthesis and XMPall subst...View the full answer

Biochemistry Concepts and Connections

Students also viewed these Medical Sciences questions