A major protein of saliva contains several hundred identical covalently attached disaccharides containing N-acetylneuraminic acid in (26)

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A major protein of saliva contains several hundred identical covalently attached disaccharides containing N-acetylneuraminic acid in α(2→6) linkage to Nacetylgalactosamine that is linked to a Ser residue. Solutions of the intact protein are extremely viscous. However, when the protein is treated with sialidase, the viscosity decreases markedly. What features of the glycoprotein structure give rise to the high viscosity and why does sialidase treatment bring about the observed change?
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Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

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