Amphotericin B is often referred to as Amphi-Terrible in medical settings due to its effects in treated patients. Describe when this drug should be prescribed, and provide a biological reason for its damaging activity on host cells.

HAART, or highly active antiretroviral therapy, is currently recommended for the treatment of HIV and involves the administration of three or more medicines at one time. Explain why this combined therapy approach is more effective than single drug treatment in the management of HIV infection, providing current evidence to support your answer.