An enzyme contains an active site aspartic acid with a pKa = 5.0, which acts as a general acid catalyst. On the template below, draw the curve of enzyme activity (reaction rate) versus pH for the enzyme (assume the protein is stably folded between pH 2-12 and that the active site Asp is the only ionizable residue involved in catalysis). Briefly explain the shape of your curve.

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% enzyme activity 1