Answer yes or no to the following questions and explain your answer.
(a) Can the absolute value of ΔG for a reaction be larger than ΔG‡?
(b) Can ΔG‡ for an enzyme-catalyzed reaction be greater than ΔG‡ for the nonenzymatic reaction?
(c) In a two-step reaction, such as the one diagrammed in Figure 11-6, must the intermediate (I) have less free energy than the reactant (A)?
(d) In a multistep reaction, does the transition state with the highest free energy always correspond to the rate-determining step?