Double-stranded DNA is a large, complex molecule, but it is not generally immunogenic unless it is associated

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Double-stranded DNA is a large, complex molecule, but it is not generally immunogenic unless it is associated with proteins or carbohydrates. Can you think why this might be so?
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Foundations in Microbiology

ISBN: 978-0073375298

8th edition

Authors: Kathleen Park Talaro, Barry Chess

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