Question: Early experiments showed that malonate, which inhibits succinate dehydrogenase, blocks cellular respiration. This led to the idea that succinate participates in oxidative metabolism as an

Early experiments showed that malonate, which inhibits succinate dehydrogenase, blocks cellular respiration. This led to the idea that succinate participates in oxidative metabolism as an intermediate and not as just another metabolic fuel. Using isotopically-labeled reagents, what observation(s) would demonstrate the validity of this interpretation?

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