Many enzyme-catalyzed reactions are consistent with a modified version of the Michaelis-Menten mechanism in which the second

Question:

Many enzyme-catalyzed reactions are consistent with a modified version of the Michaelis-Menten mechanism in which the second step is also reversible.
(a) For this mechanism show that the rate of formation of product is given by

Where v max = kd [E]0 v max = k[E]o' KM= (k: + kb)/ka, and KM= (k; + kb)/kb.
(b) Find the limiting behaviour of this expression for large and small concentrations of substrate.