Some anaerobic bacteria use an alternative pathway for glucose catabolism, shown below, that converts glucose to acetate

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Some anaerobic bacteria use an alternative pathway for glucose catabolism, shown below, that converts glucose to acetate rather than to pyruvate. The first part of this pathway (glucose to fructose-1, 6-bisphosphate) is identical to the glycolytic pathway. In the second part of the alternative pathway, Enzymes 1-6 all have mechanisms/activities analogous to enzymes in glycolysis. Note that there are two C-C bond cleavage reactions in this new pathway: A→B + C (Enzyme 1) and C→B + D. All the steps where ATP is consumed or generated have been shown; however, the addition or loss of NAD+ /NADH, Pi, H2O, or H+ has not been shown explicitly. Draw the structures for the intermediates B, F, G, H, and I, and include other reaction participants as needed.
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Biochemistry Concepts and Connections

ISBN: 978-0321839923

1st edition

Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews

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