=+. This requires setting the derivative of L() equal to 0 and solving for . However, to simplify the calculations, we first take the natural logarithm of L() 5 3

(1 2 )

7

:

ln(L()) 5 ln33

(1 2 )

7 4 5 3 ln() 1 7 ln(1 2 )

and then take the derivative1

:

d d ln(L()) 5 3

 2 7 1 2 

Example 7.15 total cholesterol under these circumstances (the cited article included this CI).