A Leu → Ala mutation at a site buried in the core of the enzyme lysozyme is found to be destabilizing. Explain the observed effect of this mutation on lysozyme stability by predicting how enthalpy (ΔH°), conformational entropy (ΔS°_peptide), and the hydrophobic effect (ΔS°_solvent) are expected to change for the mutant compared to wild-type lysozyme. Explain how ΔG° for unfolding is affected by your predicted changes in enthalpy or entropy.