Predict the effect of each of the following mutants on the rate of glycolysis in liver cells

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Predict the effect of each of the following mutants on the rate of glycolysis in liver cells (increase, decrease, no change): 

(a) Loss of the allosteric site for ATP in PFK-1 

(b) Loss of the binding site for citrate in PFK-1 

(c) Loss of the phosphatase domain of PFK-2/FBPase-2 

(d) Loss of the binding site for fructose-1,6-bisphosphate in pyruvate kinase 

(e) Loss of acetyl-CoA binding site in pyruvate carboxylase

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Biochemistry Concepts And Connections

ISBN: 9780134641621

2nd Edition

Authors: Dean Appling, Spencer Anthony-Cahill, Christopher Mathews

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