For subjects undergoing stem cell transplants, dendritic cells (DCs) are antigen-presenting cells that are critical to the generation of immunologic tumor responses. Bolwell et al. (A-2) studied lymphoid DCs in 44 subjects who underwent autologous stem cell transplantation. The outcome variable is the concentration of DC2 cells as measured by flow cytometry. One of the independent variables is the age of the subject (years), and the second independent variable is the mobilization method. During chemotherapy, 11 subjects received granulocyte colony-stimulating factor (G-CSF) mobilizer

(mg/kg/day) and 33 received etoposide (2 g=m2). The mobilizer is a kind of blood progenitor cell that triggers the formation of the DC cells. The results were as follows:

G-CSF Etoposide DC Age DC Age DC Age DC Age 6.16 65 3.18 70 4.24 60 4.09 36 6.14 55 2.58 64 4.86 40 2.86 51 5.66 57 1.69 65 4.05 48 2.25 54 8.28 47 2.16 55 5.07 50 0.70 50 2.99 66 3.26 51 4.26 23 0.23 62 8.99 24 1.61 53 11.95 26 1.31 56 4.04 59 6.34 24 1.88 59 1.06 31 6.02 60 2.43 53 6.10 24 3.14 48 10.14 66 2.86 37 0.64 52 1.87 69 27.25 63 7.74 65 2.21 54 8.21 62 8.86 69 11.33 19 6.26 43 1.44 60 Source: Data provided courtesy of Lisa Rybicki, M.S.