Gold et al. (A-5) investigated the effectiveness on smoking cessation of a nicotine patch, bupropion SR, or both, when co-administered with cognitive-behavioral therapy. Consecutive consenting patients ð Þ n ¼ 164 assigned themselves to one of three treatments according to personal preference:

nicotine patch NTP ð Þ ; n ¼ 13 , bupropion SR Bð Þ ; n ¼ 92 , and bupropion SR plus nicotine patch

ð Þ BNTP; n ¼ 59 . At their first smoking cessation class, patients estimated the number of packs of cigarettes they currently smoked per day and the numbers of years they smoked. The “pack years” is the average number of packs the subject smoked per day multiplied by the number of years the subject had smoked. The results are shown in the following table.

Pack Years NTP B BNTP 15 8 60 90 8 80 17 10 60 90 15 80 18 15 60 90 25 82 20 20 60 95 25 86 20 22 60 96 25 87 20 24 60 98 26 90 30 25 60 98 30 90 37 26 66 99 34 90 43 27 66 100 35 90 48 29 67 100 36 90 60 30 68 100 40 95 100 30 68 100 45 99 100 35 70 100 45 100 35 70 100 45 102 39 70 105 45 105 40 75 110 48 105 40 75 110 48 105 40 75 120 49 111 40 75 120 52 113 40 76 123 60 120 40 80 125 60 120 45 80 125 60 125 45 80 126 64 125 45 80 130 64 129 50 80 130 70 130 51 80 132 70 133 52 80 132 70 135 55 84 142 75 140 58 84 157 75 154 60 84 180 76 60 90 Source: Data provided courtesy of Paul B. Gold, Ph.D.