In the article “Dose uniformity of samples prepared from dispersible aspirin tablets for paediatric use” published in the European Journal of Hospital Pharmacy Science

(Broadhurst et al., 2008), the authors reported the results of a two-factor experiment on the dispersion of 75 mg aspirin tablets. The two factors in the experiment were dispersion time (3 or 5 min) and zone sampled (1, 2, 3, 4, or 5), and each of the 10 treatments was replicated 20 times. The response variable in this study was the dose of aspirin sampled with a 2 mL syringe. Use the ????-ratios and ????-values given in Table 12.42 and the means given in Table 12.43, which were reported in this article, to answer the following:

(a) On the basis of ????-ratios and their ????-values in Table 12.43, which means should be separated?

(b) On the basis of the result of part (a), determine the Bonferroni distance ???? for separating the means when MSE = 5.92 and ????E = 0.05.

(c) Separate the means.

(d) Compute a 95% confidence interval for the difference between the zone 1 and zone 5 means.