Web-based exercise. Go to the New England Journal of Medicine Web site (http://content.nejm.org) and find the article “Initial Treatment of Aggressive Lymphoma with High-Dose Chemotherapy and Autologous Stem-Cell Support” by Milpied et al. in the March 25, 2004, issue. Was this a comparative study? Was randomization used? How many subjects took part? Were the results statistically significant? (If your institution does not have a subscription to the New England Journal of Medicine, you can find an abstract of the article at www.ncbi.nlm.nih.gov/entrez/

query.fcgi?cmd=Retrieve&db=PubMed&list uids=15044639&dopt=

Abstract.)

You can find the latest medical research in the Journal of the American Medical Association (www.jama.ama-assn.org) and the New England Journal of Medicine (http://content.nejm.org). Many of the articles describe randomized comparative experiments, and even more use the language of statistical significance.

AppendixLO1