Why should determining the size of the sample take place before the sample is taken? What aspects of this determination would you consider in developing your answer? Can you set up a simple set of relationships that show your reasoning? Answer with approximately 300 words. 

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SOME ABREVIATIONS USED IN AIR POLLUTION STUDIES Full Name Airway obstructive disease Abbreviations AOD CI CO Carbon monoxide CO2 Confidence interval COPD FEV 1.0 FVC HS ICD MAX. NO2 03 OR PM 10 RR Carbon dioxide Chronic obstructive pulmonary disease Forced expiratory volume in 1 second Forced vital capacity Hydrogen sulfide International classification of diseases Maximum Nitrogen dioxide Ozone Odds ratio Particle with an aerodynamic diameter <10 mm Relative risk