Mobile genetic elements make up nearly half of the human genome and are inserted more or randomly

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Mobile genetic elements make up nearly half of the human genome and are inserted more or  randomly throughout it. However, in some spots these elements are rare, as illustrated for a cluster  genes called HoxD, which lies on Chromosome 2 (Figure Q9–10). This cluster is about 100 kb in length and contains nine genes whose differential expression along the length of the developing embryo helps establish the basic body plan for humans (and other animals). In Figure Q9–10, lines that project upward indicate exons of known genes. Lines that project downward indicate mobile genetic elements; they are so numerous they merge into nearly a solid block outside the HoxD cluster. For comparison, an equivalent region of Chromosome 22 is shown. 


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Why do you suppose that mobile genetic elements are so rare in the HoxD cluster?

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Essential Cell Biology

ISBN: 9780393680362

5th Edition

Authors: Bruce Alberts, Karen Hopkin, Alexander Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Walter

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