A certain metabolic pathway can be diagrammed as

where A, B, C, and D are the intermediates, and X, Y, and Z are the enzymes that catalyze the reactions. The physiological free energy changes for the reactions are

(a) Which reaction is likely to be a major regulatory point for the pathway?
(b) If your answer in Part a was in fact the case, in the presence of an inhibitor that blocks the activity of enzyme Z, would the concentrations of A, B, C, and D increase, decrease, or not be affected?

Transcribed Image Text:

Y ABCD