Using the results from Problem 13.74, obtain a measurement-error-corrected OR and 95% CI for each of the hormones?

The hormones in Table 13.51 were also included in the reproducibility study mentioned in Example 13.75 [36]. The intraclass correlation coefficient and sample size used for

each hormone are given in Table 13.52.

Table 13.51: Relative-risk estimates and 95% CIs for breast-cancer incidence from 1989 to June 1, 1994, in a nested case€“control study among 11,169 postmenopausal women in the NHS not taking hormone-replacement therapy in 1989, comparing women at the median value of the fourth quartile vs. women at the median value of the first quartile of the hormone distributions

 

Table 13.52: Intraclass correlation coefficients (ICCs) for selected hormones from the NHS reproducibility study, 1989

Transcribed Image Text:

Median value 1st quartile Median value 4th quartile Hormone 95% CI RR Free estradiol (%) Estrone (pg/mL) Testosterone (ng/dL) 1.33 17 1.03-2.80 1.15-3.16 1.82 45 37 1.69 1.91 1.65 1.00-2.71 12 Number of subjects with Hormone ICC 3 replicates 2 replicates Total number of measurements Free estradiol (%) Estrone (pg/mL) Testosterone (ng/dL) 237 228 237 79 0.80 0.74 72 6 0.88 79