66 Studies on treating Alzheimer’s disease. Refer to the journal eCAM (November 2006) assessment of the quality of the methodology used in studies of the treatment for Alzheimer’s disease, presented in Exercise 42 . Data on the quality of the methodology (using the Wong scale)

for each in a sample of 13 studies are reproduced in the next table and saved in the TREATAD file. According to the researchers, a study with a Wong score below 18 used a methodology that “fails to support the author’s conclusions”

about the treatment of Alzheimer’s. Use Wilson’s adjustment to estimate the proportion of all studies on the treatment of Alzheimer’s disease with a Wong score below 18. Construct a 99% confidence interval around the estimate and interpret the result

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22 21 18 19 20 15 19 20 15 20 17 20 21 Based on Chiappelli, F., et al. "Evidence-based research in complementary and alternative medicine III: Treatment of patients with Alzheimer's disease." eCAM, Vol. 3, No. 4, Nov. 2006 (Table 1).