In a study of the action potentials of heart membranes in rabbits when subjected to ischemia, membranes from 16 subjects were used. The first eight were randomly chosen and subjected to ischemia with no drug treatment applied, while the next eight were subjected to ischemia and treated with a drug—

10−4M adenosine. The action potential characteristics were measured as a percentage decrease in voltage over 120 min, observations being made every 30 min. The responses of the experiment are presented as follows:  Analyze the results of this experiment as an RMD and report on the effect of adenosine on the action potentials of the heart membranes when subjected to ischemia.

Transcribed Image Text:

Subjects No drug + ischemia Time (min) 30 60 90 120 12345678 46.95 53.68 54.61 58.67 61.26 60.14 70.58 73.83 56.98 61.15 60.06 61.74 18.58 33.07 45.35 48.18 40.33 46.72 46.55 46.20 52.78 53.84 57.78 51.91 51.85 61.90 75.43 75.31 66.98 69.71 73.65 72.86 Subjects 12345678 10M adenosine + ischemia Time (min) 30 60 90 120 48.95 46.95 46.35 47.50 47.72 46.52 44.35 42.73 42.27 41.25 60.06 40.41 30.08 23.13 45.35 25.84 58.06 56.47 46.55 55.68 37.40 43.42 57.78 45.73 33.78 40.07 75.43 42.78 46.52 48.92 73.65 50.12