In a study described in the article “Hyaluronan Impairs Vascular Function and Drug Delivery in a Mouse Model of Pancreatic Cancer” (Gut 2013: 112–120), hyaluronan was depleted from mice using either PEGPH20 or an equal dose of a standard treatment. The vessel patency (%) for each mouse was recorded.

Use a rank-sum test (as did the article’s authors) to determine if PEGPH20 yields higher vessel patency than the standard treatment at the .05 level. Would you also reject the null hypothesis at the .01 level? Comment on these results in light of the fact that every PEGPH20 measurement is higher than every standard-treatment measurement.

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PEGPH20 Standard 62 24 68 29 70 35 76 41