An abundance of misfolded proteins in the ER can result in the activation of the unfolded protein
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An abundance of misfolded proteins in the ER can result in the activation of the unfolded protein response (UPR) and ER-associated degradation (ERAD) pathways. UPR decreases the amount of unfolded proteins by altering gene expression of what type of genes? What is one manner in which ERAD may identify misfolded proteins? Why is dislocation of these misfolded proteins to the cytoplasm necessary?
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The UPR pathway upregulates transcription of protein chaperone...View the full answer
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Related Book For 
Molecular Cell Biology
ISBN: 978-1429234139
7th edition
Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott
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