Erythropoietin (Epo) is a hormone that is produced naturally in the body in response to low O

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Erythropoietin (Epo) is a hormone that is produced naturally in the body in response to low O2 levels in the blood. The intracellular events that occur in response to Epo binding to its cell surface receptor are well characterized. What molecule translocates from the cytosol to the nucleus after (a) JAK2 activates STAT5 and (b) GRB2 binds to the Epo receptor? Why did some endurance athletes use Epo to improve their performance ("blood doping") until it was banned by most sports?

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Molecular Cell Biology

ISBN: 978-1429234139

7th edition

Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott

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