What biochemical reaction is catalyzed by -secretase? Why was it proposed that a chemical inhibitor of this

Question:

What biochemical reaction is catalyzed by γ-secretase? Why was it proposed that a chemical inhibitor of this activity might be a useful drug for treating Alzheimer's disease? What possible side effects of such a drug would complicate this use?

Fantastic news! We've Found the answer you've been seeking!

Step by Step Answer:

Related Book For book-img-for-question

Molecular Cell Biology

ISBN: 978-1429234139

7th edition

Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott

See More Books

Question Posted: Apr 17, 2018 07:25 AM

See More Questions

Each gram of mammalian skeletal muscle consumes ATP at a rate of about 1 Ã 10-3 mol/min during contraction. To bridge the short interval between the moderate demand for ATP met by aerobic...
Staphylococcus nuclease is an enzyme that catalyzes the hydrolysis of DNA. The overall hydrolysis reaction is as follows: Recall that the nucleotides in DNA have phosphodiester linkages. The reaction...
Sugars, being polyhydroxylic compounds, undergo reactions characteristic of alcohols. In one of the later steps in glycolysis (the metabolism of glucose), one of the glucose metabolites with a...
An investment project has annual cash inflows of $3,200, $4,100, $5,300, and $4,500, and a discount rate of 14 percent. What is the discounted payback period for these cash flows if the initial cost...
The length of stay at a specific emergency department in Phoenix, Arizona, had a mean of 4.6 hours. Assume that the length of stay is exponentially distributed. a) What is the standard deviation of...
How can automatic transfers help you save money?
A stock dividend __________ the number of shares outstanding and __________ the price of the stock.
The Farmyard Gate A gate 4.00 m wide and 2.00 m high weighs 500 N. Its center of gravity is at its center, and it is hinged at A and B. To relieve the strain on the top hinge, a wire CD is connected...
Lando Calrissian just won the lottery and is trying to decide between the options of receiving the annual cash flow payment option of $430,000 per year for 20 years beginning today, or receiving one...
Richard chooses technique 0 and 2 requiring 10+10-20 efforts and provising 10+11=21 benefits. Hence, 21 is returned as the output Example 2: input1: 3 input2: (10,10,10,10) input3: (10,11,12,15)...
What feature of Delta ensures that only neighboring cells are signaled?
1. G. Johnson and colleagues have analyzed the MAP kinase cascade in which MEKK2 participates in mammalian cells. By a yeast two-hybrid screen (see Chapter 7), MEKK2 was found to bind MEK5, which can...
What are the advantages and disadvantages of being a first mover in an industry? Give some examples of first mover and late mover firms. Were they successful?
Everyone at some point has had issues with time management and procrastination in their work life, academic life and social life. How have you been handling time management issues in your life? Have...
You want to make three peanut butter and jelly sandwiches. What is the best way to make them that's consistent with an agile mindset? Create a sandwich assembly line, applying all the peanut butter...
1 pts Joan Reed exchanges commercial real estate that she owns for other commercial real estate, plus $50,000 cash. The following additional information pertains to this transaction: Property given...
It is believed that 86% of Padres fans would have liked Trevor Hoffman to remain in San Diego to finish out his career as a San Diego Padre. You would like to simulate asking 10 Padres fans their...
The videos below cover why American higher education, including public colleges and universities, is so expensive. They also explore factors that have resulted in the current student loan debt...
A routine activity such as pumping gasoline can be related to many of the concepts studied in this text. Suppose that premium unleaded costs $3.75 per gal. Work Exercises in order. Use the...
After looking at the resources, explain what a spirit image is. Why might looking at a god and/or a human in terms of their spirit be helpful if you want to eliminate some of the divisions between...
What mechanistic features are shared by (a) The formation of multivesicular endosomes by budding into the interior of the endosome and (b) The outward budding of HIV virus at the cell surface? You...
The phagocytic and autophagic pathways serve two fundamental roles, but both deliver their vesicles to the lysosome. What arc the fundamental differences between the two pathways? Describe the three...
Compare and contrast the location and pH sensitivity of receptor-ligand interaction in the LDL and transferrin receptor-mediated endocytosis (RME) pathways?
Phantom Consulting Inc. is a small computer consulting business. The company is organized as a corporation and provides consulting services, computer system installations, and custom program...
Sam owns a 25% in Spade, LLC. In 2021, Spade reports $100,000 or ordinary income. What is Sams qualified business income (QBI) deduction? answer is 5,000 but please show how to get it
crane Inc. common chairs currently sell for $30 each. The firms management believes that it's share should really sell for $54 each. If the firm just paid an annual dividend of two dollars per share...

What biochemical reaction is catalyzed by -secretase? Why was it proposed that a chemical inhibitor of this

Question:

Step by Step Answer:

secretase is an intramembrane protease When it was found that gsecretase cleaves the intramem...View the full answer

Molecular Cell Biology

Students also viewed these Life Sciences questions