What is the functional definition of START? Cancer cells typically lose START control. Explain how the following

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What is the functional definition of START? Cancer cells typically lose START control. Explain how the following mutations, which arc found in some cancer cells, lead to a bypass of START controls:

(a) Over-expression of cyclin D,

(b) Loss of Rb function,

(d) Hyperactive E2F?

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Molecular Cell Biology

ISBN: 978-1429234139

7th edition

Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott

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Question Posted: Apr 17, 2018 08:03 AM

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What is the functional definition of START? Cancer cells typically lose START control. Explain how the following

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START represents a point in the cell cycle beyond which cells are irrevocably committed to completin...View the full answer

Molecular Cell Biology

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