In the Krebs cycle (tricarboxylic acid, or citric acid, cycle), the enzyme citrate synthase catalyzes the synthesis of citrate from oxaloacetate and acetyl-CoA as shown in Fig. P22.96. Assuming that acids and bases are provided as needed in the enzyme active site, propose a curvedarrow mechanism for this reaction.

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H₂O + 0-C- Figure P22.96 CH₂-C-O + H₂C-C-SCOA acetyl-CoA oxalacetate citrate synthase OH oltato CH₂ CH₂- C-O + COASH + H3O+ citrate