As an application of Problems 10, 11 and 12, consider the estimation of haplotype frequencies from a
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As an application of Problems 10, 11 and 12, consider the estimation of haplotype frequencies from a random sample of people who are genotyped at the same linked, codominant loci. The resulting multilocus genotypes lack phase. Find an explicit upper bound on the expected information matrix for the haplotype frequencies and an explicit lower bound on the standard error of each estimated frequency. (Hints: The complete data specify phase. For the standarderror bound, use the Sherman-Morrison formula.)
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