In this exercise, treat the components as simple (reactive) chemical species and perform the appropriate (dynamic) material

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In this exercise, treat the components as simple (reactive) chemical species and perform the appropriate (dynamic) material balance. Assume that a messenger RNA mRNA is produced by a constant (basal) expression rate from a particular gene. In addition, assume that the mRNA degrades according to a frst-order decay rate. 

(a) Write the equation for the dynamics of the mRNA concentration as a function of the expression rate G0 and the decay rate constant kd mRNA.

(b) Assume that each mRNA molecule is translated to form p copies of a protein product, P. Furthermore, the protein is subject to first-order degradation, with a decay rate constant kP mRNA. Write the equation for the dynamics of the protein concentration.

(c) Assume that the system has been operating for some time at a constant gene expression rate G0, and then the expression rate changes instantaneously to a value G1. Derive an analytical expression for the transient responses for mRNAand P.

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Process Dynamics And Control

ISBN: 1602

4th Edition

Authors: Dale E. Seborg, Thomas F. Edgar, Duncan A. Mellichamp, Francis J. Doyle

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