In this exercise, treat the components as simple (reactive) chemical species and perform the appropriate (dynamic) material
Question:
In this exercise, treat the components as simple (reactive) chemical species and perform the appropriate (dynamic) material balance. Assume that a messenger RNA mRNA is produced by a constant (basal) expression rate from a particular gene. In addition, assume that the mRNA degrades according to a frst-order decay rate.
(a) Write the equation for the dynamics of the mRNA concentration as a function of the expression rate G0 and the decay rate constant kd mRNA.
(b) Assume that each mRNA molecule is translated to form p copies of a protein product, P. Furthermore, the protein is subject to first-order degradation, with a decay rate constant kP mRNA. Write the equation for the dynamics of the protein concentration.
(c) Assume that the system has been operating for some time at a constant gene expression rate G0, and then the expression rate changes instantaneously to a value G1. Derive an analytical expression for the transient responses for mRNAand P.
Step by Step Answer:
Process Dynamics And Control
ISBN: 1602
4th Edition
Authors: Dale E. Seborg, Thomas F. Edgar, Duncan A. Mellichamp, Francis J. Doyle