1. “7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one” is the IUPAC
nomenclature of which drug?
a) Trihexyphenidyl
b) Propantheline
c) Oxybutynin
d) Oxazepam

2. Match the following with correct classifications of the drugs.
i. Propantheline A. Benzodiazepine sedative-hypnotic
ii. Oxazepam B. Barbiturate
iii. Clozapine C. Muscarinic antagonist
iv. Thiamylal D. Benzpines
a) i-A, ii-C, iii-D, iv-B
b) i-C, ii-A, iii-D, iv-B
c) i-A, ii-B, iii-D, iv-C
d) i-C, ii-B, iii-A, iv-D

3. Mechanism of action of oxazepam is based on?
a) Blocking the Muscarinic acetylcholine receptors
b) Blocking the nicotinic acetylcholine receptors
c) Increasing the inhibitory effects of GABA
d) Both a) and c)

4. Correct sequence for True and False for the given statements related with the SAR of drug
trihexyphenidyl
· Ring A should include an aromatic or heteroaromatic ring for binding with 5-phenyl-1,4-
benzodiazepin-2-one derivatives.
· An electronegative group at 7-position of the ring A decreases the functional anxiolytic
activity.
· Substitutions at 6, 8 or 9 position with electronegative group on ring A will decrease the
functional anxiolytic activity.
· When Heterocycles used as ring A, drug shows best pharmacological activity.
a) TFTF
b) FTFT
c) TTTT
d)FFTF