1. A double-blind trial was conducted with 15,828 patients with stable coronary heart disease to test the efficacy of a new drug darapladib compared to placebo with respect to lowering rates of coronary events. The data in the table below are taken from a secondary endpoint collected in this trial.

	Placebo (N=7904)	Darapladib (N=7924)
Major Coronary Events*	814 (10.3%)	737 (9.3%)

* Includes Death from Coronary heart disease, Nonfatal myocardial infarction & Urgent coronary revascularization

Reference:https://www.nejm.org/doi/full/10.1056/NEJMoa1315878

Note: The data in the actual trial were analyzed appropriately using time-to-event analyses (not covered in our course) which account for patients dropping out and having varying follow-up times. The analyses requested below for this exam will assume no dropouts and that each person was followed for the same amount of time so that we can use methods covered in SPHG 711. Thus the results requested below are NOT included in the referenced manuscript.

1a. [0 points] Use the information in the table above to complete the following table with counts and percentages in the 2x2 table format.

	Major Coronary Events
	Yes n (%)	No n (%)	Total
Placebo	814 (10.3%)	7090 (89.7%)	7904
Darapladib	737 (9.3%)	7187 (90.7%)	7,924
Total	1,551	14,277	15,828

1a. ANSWER

	Major Coronary Events
	Yes n (%)	No n (%)	Total
Placebo	814 (10.3%)	7090 (89.7%)	7904
Darapladib	737 (9.3%)	7187 (90.7%)	7,924
Total	1,551	14,277	15,828

1b. [1.5 points]Calculate the odds ratioof having a major coronary event in the placebo group compared to the darapladib group.

Interpret the ORin the context of this scenario.

Provide a 95% confidence interval for the odds ratio.

Interpret the confidence interval (including any conclusions we can make regarding the null value being in the interval). An interpretation of a CI should contain the concept of repeated sampling. Recall you have a handout about interpreting a CI correctly.

[Note: No need to provide assumptions or conduct a hypothesis test. Just calculate and interpret OR, calculate and interpret the confidence interval as requested. Include relevant computer output or show all calculations.]

1b. ANSWER

. cci 814 7090 737 7187 Proportion Exposed Unexposed Total exposed Cases 814 7090 7904 0.1030 Controls 737 7187 7924 0. 0930 Total 1551 14277 15828 0.0980 Point estimate [95% Conf. Interval] Odds ratio 1. 119588 1.00667 1. 245179 (exact) Attr. frac. ex. .1068145 .0066263 .1969029 (exact) Attr. frac. pop . 0110904 chi2(1) = 4.46 Pr>chi2 = 0.0348