1. A pharmaceutical manufacturer wants o determine the concentration of a key component of cough medicine that may be used without the drugs causing adverse side effects. As part of the analysis, a random sample of 45 patients is administered doses of varying concentration (X), and the severity of side effects (Y) is measured. The results include x-bar = 88.9, y-bar = 165.3, SSx = 2,133.9, SSxy = 4.502.53, SSy = 12,500. Required: a. Find the least squares estimates of the regression parameter. 2. Discuss the advantages of least-squares procedure for fitting lines to data, explain how the procedure works